Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands

The chemokine receptor CXCR4 and its ligand CXCL12 regulate leukocyte trafficking, homeostasis and functions and are potential therapeutic targets in many diseases such as HIV-1 infection and cancers.Here, we identified new CXCR4 ligands in the CERMN chemical library using a FRET-based high-throughput screening assay.These are bis-imidazoline compo

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Muslim Tatars of the Nekrashun Parish: History and Modernity

The article follows the Nekrashun parish of Tatar-Muslim origin on various deep historical processes, from its origin to the present day.The purpose of the article is the observe features of the social and cultural life of the Tatars of the Nekrashun parish, to consider the role of Islamic traditions and the local mosque in the life of the populati

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